Monday Night Football: How to watch the San Francisco 49ers vs. Indianapolis Colts NFL game tonight

Philip Rivers will start once again for the Indianapolis Colts when the team faces the San Francisco 49ers in the Week 16 edition of Monday Night Football. The 8-6 Colts will host the 10-4 49ers at Lucas Oil Stadium. The Colts have slim chances of making the playoffs while the 49ers can clinch their playoff spot with a win on Monday.

You can tune into Monday Night Football’s 49ers vs. Colts game on ESPN and ABC, which are available on streaming platforms like ESPN Unlimited and DirecTV. The MNF game will also be simulcast on Disney+, a first for the streamer; it’ll be available for all standalone subscribers, no ESPN or Hulu bundle necessary. Here’s what you need to know to tune in to this week’s game.

How to watch the San Francisco 49ers vs. Indianapolis Colts:

Date: Monday, Dec. 22, 2025

Time: 8:15 p.m. ET

TV channels: ESPN, ABC

Streaming: Disney+, Fubo, DirecTV, ESPN Unlimited, NFL+ and more

San Francisco 49ers vs. Indianapolis Colts game time:

The 49ers vs. Colts game kicks off at 8:15 p.m. ET/5:15 p.m. PT this Monday, Dec. 22, 2025.

San Francisco 49ers vs. Indianapolis Colts game channel:

The Week 16 game between the 49ers and the Colts will air on ESPN and ABC.

How to watch the San Francisco 49ers vs. Indianapolis Colts game without cable:

You can tune in to ESPN and ABC through your cable provider, or on streaming platforms like DirecTV, Fubo and more. You can also stream the game on the ESPN App with ESPN Unlimited, on Disney+, or with NFL+ (via phone or tablet only).

all the options for subscribing to a standalone Disney+ plan, or a bundle.

Sling Orange, which includes ESPN, ESPN2, TNT, Disney Channel, and 30 more with no other subscriptions or commitment necessary. No strings attached.

NFL Week 16 schedule:

All times Eastern.

Thursday, Dec. 18, 2025

Saturday, Dec. 20, 2025

Eagles vs. Commanders: 5:00 p.m. (FOX)
Packers vs. Bears: 8:20 p.m. (FOX)

Sunday, Dec. 21, 2025

Bills vs. Browns: 1:00 p.m. (CBS)
Vikings vs. Giants: 1:00 p.m.(FOX)
Buccaneers vs. Panthers: 1:00 p.m. (FOX)
Chargers vs. Cowboys: 1:00 p.m. (FOX)
Jets vs. Saints: 1:00 p.m. (CBS)
Chiefs vs. Titans: 1:00 p.m.(CBS)
Bengals vs. Dolphins: 1:00 p.m. (CBS)
Falcons vs. Cardinals: 4:05 p.m. (FOX)
Jaguars vs. Broncos: 4:05 p.m. (FOX)
Steelers vs. Lions: 4:25 p.m. (CBS)
Raiders vs. Texans: 4:25 p.m. (CBS)
Patriots vs. Ravens: 8:20 p.m. (NBC)

Monday, Dec. 22, 2025

How to watch NFL games in 2025:

Many NFL games are broadcast on local channels, so if you’re looking to catch an in-market game, it may be as simple as turning on your TV (or setting up a digital TV antenna) or finding a live TV streaming service that carries the correct RSN (Regional Sports Network). If you want to watch out-of-market games, a $7 monthly subscription to NFL+ will let you watch every out-of-market local and primetime game in the season on your phone — but only a select few regular-season games on your TV. You could also spring for the uber-expensive NFL Sunday Ticket package to get every out-of-market Sunday game of the season.

When it comes to nationally broadcast games, NFL games typically air across ESPN, NBC, CBS, Fox, ABC and NFL Network. Thursday Night Football games stream exclusively on Amazon Prime Video, select football games will stream exclusively on Peacock, games on CBS will stream live on Paramount+, and Monday Night Football games will air on ESPN or ABC and stream on the newly revamped ESPN+ this season. That’s six channels and four streaming platforms to keep up with this season — and that’s not counting your local RSN’s for in-market games and an NFL+ or NFL Sunday Ticket subscription for out-of-market games. Plus, Netflix is once again hosting at least two Christmas Day matches, so add that subscription into the mix. And we can’t forget about Fox One, Fox’s first streaming service, a place where you can also stream games airing on FOX (if you don’t already have access to it).

Confused? You’re not alone. Here’s a breakdown of the platforms we recommend checking out during the 2025 NFL season, so that come game time, tuning into your favorite team’s games will be as easy as simply turning on the TV.